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KMID : 0604020100250030168
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Korean Journal of Critical Care Medicine
2010 Volume.25 No. 3 p.168 ~ p.171
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The Management of Heparin-induced Thrombocytopenia with Thrombosis after Open Heart Surgery
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Kim Jae-Bum
Choi Sae-Young
Park Nam-Hee
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Abstract
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Heparin-induced thrombocytopenia (HIT) is a prothrombotic, immune-mediated adverse reaction to heparin therapy. It is caused by antibodies binding to a complex of heparin and platelet factor 4, and this leads to platelet activation, excessive thrombin generation and often thrombosis. HIT with thrombosis (HITT) can lead to limb amputation, stroke, myocardial infarction and death. We report here on a case of a HITT patient who was successfully managed with argatroban therapy. Further knowledge is need about the ideal medical management for HITT.
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KEYWORD
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agatroban, heparin therapy, thrombocytopenia, thrombosis
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